As the global land area of biotechnology-derived crops continues to increase, these crops have become an increasingly important source of feedstuffs for farm animals, and it is important to review the safety of meat, milk, and eggs derived from animals fed these crops. This paper addresses topics including an overview of regulatory assessments for biotechnology-derived crops modified for agronomic input traits; comparative safety assessment process; results of feeding studies in farm animals; and the fate of consumed proteins and DNA in livestock.