This commentary evaluates how agricultural science and technology can support implementation of the federal Climate 21 Project, which positions the U.S. Department of Agriculture as a central actor in national climate mitigation and resilience strategies. Agriculture and forestry are highlighted as the only major sectors capable of becoming net greenhouse gas sinks, offering substantial potential to help the United States reach net‑zero emissions by 2050 through soil carbon sequestration, improved nutrient management, reduced tillage, and strengthened crop and livestock systems.