This report explores the potential for U.S. agriculture to achieve greenhouse gas (GHG) neutrality or become GHG-negative by integrating current and emerging practices across crop and livestock systems. The analysis identifies five major opportunity areas: soil carbon management, nitrogen fertilizer management, animal production and manure handling, crop production efficiency, and on-farm energy use. The report emphasizes the need for on-farm demonstrations, technical support, and policy incentives to overcome economic and technological barriers.