This Special Publication describes the biology and agronomic practices in alfalfa that should be considered in developing coexistence strategies to allow growers to have choices, specifically between genetically engineered (GE), conventional, and GE-sensitive markets in the United States. These strategies are based on science and are a direct extension of well-established coexistence principles routinely used by seed growers. The management practices currently being used by growers of Roundup Ready alfalfa seed are presented as an example of strategies developed by the alfalfa seed industry that allow coexistence of different production systems.