This commentary evaluates how agricultural science and technology can support implementation of the federal Climate 21 Project, which positions the U.S. Department of Agriculture as a central actor in national climate mitigation and resilience strategies. Agriculture and forestry are highlighted as the only major sectors capable of becoming net greenhouse gas sinks, offering substantial potential to help the United States reach net‑zero emissions by 2050 through soil carbon sequestration, improved nutrient management, reduced tillage, and strengthened crop and livestock systems. The document synthesizes scientific knowledge and identifies opportunities to scale climate‑smart practices across plant, soil, animal, and food systems. Key strategies include conservation agriculture to improve soil health and water efficiency; precision nutrient, water, and pest management to reduce nitrous oxide emissions; integrated pest management and conservation tillage to cut fuel use and enhance carbon storage; and innovations in animal agriculture that target methane mitigation, improved feed efficiency, and whole‑farm greenhouse gas modeling. The commentary also highlights emerging tools such as precision agriculture, remote sensing, advanced breeding, and improved soil carbon measurement technologies that can accelerate adoption and strengthen measurement, reporting, and verification.